The effect of eating on the uptake of PSMA ligands in the salivary glands.

ABSTRACT:

Rationale

PSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of ¹⁷⁷Lu/²²⁵Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xerostomia and potentially severe effect on the quality of life. Gustatory stimulation is an approach that has commonly been used in radioactive iodine therapy to reduce accumulation in the salivary glands. However, based on theoretical differences in biodistribution, it was hypothesized that this could potentially lead to adverse increased toxicity for PSMA-ligand therapy. The primary objective of this work was to determine if gustatory stimulation by eating an assortment of sweet/fatty/acidic foods during the biodistribution phase of [¹⁸

SUBMITTER: Mohan V 

PROVIDER: S-EPMC8473516 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature