Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO₂ spectrum.

ABSTRACT:

Background & aims

Significantly worse survival has been reported in patients with hepatopulmonary syndrome (HPS) and partial pressure of arterial oxygen (PaO₂) <45 mmHg undergoing liver transplantation. Long-term pre- and post-transplant outcomes based on degree of hypoxaemia were re-examined.

Methods

A retrospective analysis of 1,152 HPS candidates listed with an approved HPS model for end-stage liver disease (MELD) exception was performed. A Fine and Gray competing risks model was utilised to evaluate pre-transplant outcomes for PaO₂ thresholds of <45, 45 to <60, and ≥60 mmHg. Post-transplant survival was analysed using the Kaplan-Meier method.

Results

Patients with a PaO₂ <45 mmHg were significantly more likely to undergo transplant

SUBMITTER: Kadry Z 

PROVIDER: S-EPMC8473556 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature