The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis.

ABSTRACT: A hormonal imbalance may disrupt the rigorously monitored cellular microenvironment by hampering the natural homeostatic mechanisms. The most common example of such hormonal glitch could be seen in obesity where the uprise in adipokine levels is in virtue of the expanding bulk of adipose tissue. Such aberrant endocrine signaling disrupts the regulation of cellular fate, rendering the cells to live in a tumor supportive microenvironment. Previously, it was believed that the adipokines support cancer proliferation and metastasis with no direct involvement in neoplastic transformations and tumorigenesis. However, the recent studies have reported discrete mechanisms that establish the direct involvement of adipokine signaling in tumorigenesis. Moreover, the individual adipokine profile of the

SUBMITTER: Umar MI 

PROVIDER: S-EPMC8473628 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature