An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites.

ABSTRACT: Proliferation of Plasmodium falciparum in red blood cells is the cause of malaria and is underpinned by an unconventional cell division mode, called schizogony. Contrary to model organisms, P. falciparum replicates by multiple rounds of nuclear divisions that are not interrupted by cytokinesis. Organization and dynamics of critical nuclear division factors remain poorly understood. Centriolar plaques, the centrosomes of P. falciparum, serve as microtubule organizing centers and have an acentriolar, amorphous structure. The small size of parasite nuclei has precluded detailed analysis of intranuclear microtubule organization by classical fluorescence microscopy. We apply recently developed super-resolution and time-lapse imaging protocols to describe microtubule reconfi

SUBMITTER: Simon CS 

PROVIDER: S-EPMC8473725 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature