Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies.

ABSTRACT: Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superio

SUBMITTER: Zackova L 

PROVIDER: S-EPMC8473769 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature