Analysis of Brain Functional Connectivity Neural Circuits in Children With Autism Based on Persistent Homology.

ABSTRACT: Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder with a complex and unknown etiology. Statistics demonstrate that the number of people diagnosed with ASD is increasing in countries around the world. Currently, although many neuroimaging studies indicate that ASD is characterized by abnormal functional connectivity (FC) patterns within brain networks rather than local functional or structural abnormalities, the FC characteristics of ASD are still poorly understood. In this study, a Vietoris-Rips (VR) complex filtration model of the brain functional network was established by using resting-state functional magnetic resonance imaging (fMRI) data of children aged 6-13 years old [including 54 ASD patients and 52 typical development (TD) controls] from the Autism Brain Imagi

SUBMITTER: Liang D 

PROVIDER: S-EPMC8473898 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature