Testing gene-environment interactions in the presence of confounders and mismeasured environmental exposures.

ABSTRACT: Interest in investigating gene-environment (GxE) interactions has rapidly increased over the last decade. Although GxE interactions have been extremely investigated in large studies, few such effects have been identified and replicated, highlighting the need to develop statistical GxE tests with greater statistical power. The reverse test has been proposed for testing the interaction effect between continuous exposure and genetic variants in relation to a binary disease outcome, which leverages the idea of linear discriminant analysis, significantly increasing statistical power comparing to the standard logistic regression approach. However, this reverse approach did not take into consideration adjustment for confounders. Since GxE interaction studies are inherently nonexperimental, adjust

SUBMITTER: Cheng C 

PROVIDER: S-EPMC8473983 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature