Moderate noise associated oxidative stress with concomitant memory impairment, neuro-inflammation and neurodegeneration.

ABSTRACT: Noise, a disturbing and unwanted sound is currently being perceived as a widespread environmental stressor. In the present study we investigated the activation of oxidative stress as a mechanism involved in cognitive impairment through changes in neuro-inflammation. Sprague Dawley rats (200-220 ​ ​g ​m) were exposed to moderate (100dB) sound pressure level (SPL) noise daily for 2 ​h ​s over a period of 15 and 30 days and the consequence on brain regions of hippocampus observed through behavioral studies by Morris Water Maze to assess effects on spatial memory coupled with biochemical evaluation of markers of oxidative stress and inflammation. Further, the underlying mechanism pertaining to apoptosis was investigated by immuno-histological studies through assessment of Caspase-3 and TUNEL a

SUBMITTER: Shukla M 

PROVIDER: S-EPMC8474184 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature