Exercise-induced modulation of monocytes in breast cancer survivors.

ABSTRACT:

Background

Exercise training reduces inflammation in breast cancer survivors; however, the mechanism is not fully understood.

Objectives

The effects of acute and chronic exercise on monocyte toll-like receptor (TLR2 and 4) expression and intracellular cytokine production were examined in sedentary breast cancer survivors.

Methods

Eleven women with stage I, II, or III breast cancer within one year of treatment completion performed an acute, intermittent aerobic exercise trial. Blood samples were obtained before, immediately, and 1 h after a 45-min acute exercise trial that was performed before and after 16 weeks of combined aerobic and resistance. LPS-stimulated intracellular IL-1ß, TNF, and IL-6 production, and TLR2 and TLR4 expression were evaluated in CD14⁺

SUBMITTER: Khosravi N 

PROVIDER: S-EPMC8474256 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature