Which exercise and behavioural interventions show most promise for treating fatigue in multiple sclerosis? A network meta-analysis.

ABSTRACT:

Background

Fatigue is a common, debilitating symptom of multiple sclerosis (MS) without a current standardised treatment.

Objective

The aim of this systematic review with network meta-analyses was to estimate the relative effectiveness of both fatigue-targeted and non-targeted exercise, behavioural and combined (behavioural and exercise) interventions.

Methods

Nine electronic databases up to August 2018 were searched, and 113 trials (n = 6909) were included: 34 were fatigue-targeted and 79 non-fatigue-targeted trials. Intervention characteristics were extracted using the Template for Intervention Description and Replication guidelines. Certainty of evidence was assessed using GRADE.

Results

Pairwise meta-analyses showed that exercise interventions demons

SUBMITTER: Harrison AM 

PROVIDER: S-EPMC8474304 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature