Functional brain network organization measured with magnetoencephalography predicts cognitive decline in multiple sclerosis.

ABSTRACT:

Background

Cognitive decline remains difficult to predict as structural brain damage cannot fully explain the extensive heterogeneity found between MS patients.

Objective

To investigate whether functional brain network organization measured with magnetoencephalography (MEG) predicts cognitive decline in MS patients after 5 years and to explore its value beyond structural pathology.

Methods

Resting-state MEG recordings, structural MRI, and neuropsychological assessments were analyzed of 146 MS patients, and 100 patients had a 5-year follow-up neuropsychological assessment. Network properties of the minimum spanning tree (i.e. backbone of the functional brain network) indicating network integration and overload were related to baseline and longitudinal cognition, correc

SUBMITTER: Nauta IM 

PROVIDER: S-EPMC8474326 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature