Repurposing haloperidol for the treatment of rheumatoid arthritis: an integrative approach using data mining techniques.

ABSTRACT:

Introduction

Treatment of rheumatoid arthritis (RA) has advanced with the introduction of biological disease-modifying antirheumatic drugs. However, more than 20% of patients with RA still have moderate or severe disease activity. Hence, novel antirheumatic drugs are required. Recently, drug repurposing, a process of identifying new indications for existing drugs, has received great attention. Furthermore, a few reports have shown that antipsychotics are capable of affecting several cytokines that are also modulated by existing antirheumatic drugs. Therefore, we investigated the association between antipsychotics and RA by data mining using real-world data and bioinformatics databases.

Methods

Disproportionality and sequence symmetry analyses were employed to identify the as

SUBMITTER: Nakagawa C 

PROVIDER: S-EPMC8474350 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature