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ABSTRACT: Introduction
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that is estimated to be carried by one-third of the world population. Latent T. gondii infection has been linked to several neuropsychiatric mood disorders and behaviors. The aim of the present study was to examine whether T. gondii seropositivity is associated with affective disorders, as well as with aggression reactivity and suicidal thoughts.Methods
In the Netherlands Study of Depression and Anxiety (NESDA), T. gondii antibodies were assessed in patients with current depressive (n = 133), anxiety (n = 188), comorbid depressive and anxiety (n = 148), and remitted disorders (n = 889), as well as in healthy controls (n = 373) based on DSM-IV criteria. Seropositivity was analyzed in relation to disorder status, aggression reactivity and suicidal thoughts using multivariate analyses of covariance and regression analyses.Results
Participants were on average 51.2 years (SD = 13.2), and 64.4% were female. Seropositivity was found in 673 participants (38.9%). A strong positive association between T. gondii seropositivity and age was observed. No significant associations were found between T. gondii seropositivity and disorder status, aggression reactivity and suicidal thoughts. The adjusted odds ratio (OR) for any remitted disorder versus controls was 1.13 (95% CI: 0.87-1.49), and for any current disorder versus controls was 0.94 (95% CI: 0.69-1.28).Conclusions
No evidence was found for a relationship between affective disorders and T. gondii infection in the current sample.
SUBMITTER: de Bles NJ
PROVIDER: S-EPMC8474384 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
de Bles Nienke J NJ van der Does Juliette E H JEH Kortbeek Laetitia M LM Hofhuis Agnetha A van Grootheest Gerard G Vollaard Albert M AM Schoevers Robert A RA van Hemert Albert M AM Penninx Brenda W J H BWJH Rius-Ottenheim Nathaly N Giltay Erik J EJ
Brain, behavior, & immunity - health 20201231
<h4>Introduction</h4><i>Toxoplasma gondii (T. gondii)</i> is an obligate intracellular parasite that is estimated to be carried by one-third of the world population. Latent <i>T. gondii</i> infection has been linked to several neuropsychiatric mood disorders and behaviors. The aim of the present study was to examine whether <i>T. gondii</i> seropositivity is associated with affective disorders, as well as with aggression reactivity and suicidal thoughts.<h4>Methods</h4>In the Netherlands Study o ...[more]