High-Grade Neuroendocrine Carcinoma Within a Tracheal Polyp: A Case Report.

ABSTRACT:

Introduction

Primary carcinomas of the trachea are rare, with a reported annual incidence of one in a million. We present a case of a previously undescribed polypoid high-grade neuroendocrine carcinoma of the trachea. Resection of the carcinoma revealed only superficial invasion of the mucosa and without evidence of local or distant metastatic disease. Histologically, the tumor had high-grade features with necrosis and a high mitotic index.

Methods

Characterization of this rare neuroendocrine carcinoma of the trachea was performed by immunohistochemistry and whole-genome sequencing.

Results

Immunohistochemistry result was positive for neuroendocrine markers, p16 and an elevated Ki-67. Whole-genome sequencing of the lesion was performed and revealed a very unusual and

SUBMITTER: Brochu V 

PROVIDER: S-EPMC8474438 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature