Strain and sex differences in somatosensation and sociability during experimental autoimmune encephalomyelitis.

ABSTRACT: Multiple Sclerosis (MS) is an immune-mediated disease that results in major locomotor deficits. However, recent studies have revealed that fatigue, slow processing speed, and memory impairment are the top variables impacting employment status for MS patients. These suggest that cognitive effects may have a greater impact on productivity, lifestyle, and quality of life than do disease-related motor deficits. However, these debilitating non-locomotive effects have been largely overlooked in rodent models of the disease, such as experimental autoimmune encephalomyelitis (EAE). We hypothesized that murine EAE can also be used to assess non-locomotive dysfunctions (mood, sociability, muscle strength, and balance), as well as potential biases in these dysfunctions due to sex and/or strain. We ac

SUBMITTER: Ondek K 

PROVIDER: S-EPMC8474462 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature