Memantine can protect against inflammation-based cognitive decline in geriatric depression.

ABSTRACT:

Introduction

Geriatric depression is frequently accompanied by cognitive complaints and inflammation that increase risk for treatment-resistant depression and dementia. Memantine, a neuroprotective drug, can improve depression, inflammation, and help prevent cognitive decline. In our six-month clinical trial, escitalopram/memantine (ESC/MEM) improved mood and cognition compared to escitalopram/placebo treatment (ESC/PBO; NCT01902004). In this report, we examined the impact of baseline inflammation on mood and cognitive outcomes.

Materials and methods

We measured a panel of inflammatory cytokine markers using Human 38-plex magnetic cytokine/chemokine kits (EMD Millipore, HCYTMAG-60K-PX38) in 90 older adults 60 years and older with major depression enrolled in a 6-month double

SUBMITTER: Van Dyk K 

PROVIDER: S-EPMC8474499 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature