Neuroinflammation in World Trade Center responders at midlife: A pilot study using [¹⁸F]-FEPPA PET imaging.

ABSTRACT:

Background

Neuroinflammation has long been theorized to arise from exposures to fine particulate matter and to be modulated when individuals experience chronic stress, both of which are also though to cause cognitive decline in part as a result of neuroinflammation.

Objectives

Hypothesizing that neuroinflammation might be linked to experiences at the World Trade Center (WTC) events, this study explored associations between glial activation and neuropsychological measures including post-traumatic stress disorder (PTSD) symptom severity and WTC exposure duration.

Methods

Translocator protein 18-kDa (TSPO) is overexpressed by activated glial cells, predominantly microglia and astrocytes, making TSPO distribution a putative biomarker for neuroinflammation. Twenty WTC resp

SUBMITTER: Deri Y 

PROVIDER: S-EPMC8474562 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature