Evidence of altered salivary cytokine concentrations in Rett syndrome and associations with clinical severity

ABSTRACT:

Background

Immune dysregulation may play a role in the development of Rett syndrome (RTT), a neurodevelopmental disorder caused by mutations of the MECP2 gene. Abnormal cytokine concentrations have been documented in the serum of individuals with RTT. Measurement of salivary cytokines has been investigated as a potential alternative approach to measurement in blood and serum, but it is unclear whether salivary cytokine concentrations can provide valid information about systemic immune function in neurodevelopmental disorders. The goal of this study was to evaluate the potential validity of salivary cytokines as biomarkers of immune dysregulation in RTT.

Methods

Saliva samples from 16 individuals with RTT (all female; age range 2–40 years) and 16 healthy control females (a

SUBMITTER: Byiers B 

PROVIDER: S-EPMC8474566 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature