Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans.

ABSTRACT: Data from clinical and cross-sectional studies suggest that inflammation contributes to psychomotor slowing and attentional deficits found in depressive disorder. However, experimental evidence is still lacking. The aim of this study was to clarify the effect of inflammation on psychomotor slowing using an experimental and acute model of inflammation, in which twenty-two healthy volunteers received an intravenous injection of lipopolysaccharide (LPS, dose: 0.8 ​ng/kg body weight) and of placebo, in a randomized order following a double-blind within-subject crossover design. A reaction time test and a go/no-go test were conducted 3 ​h after the LPS/placebo injection and interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were assessed. No effect of experimental inflammation

SUBMITTER: Handke A 

PROVIDER: S-EPMC8474655 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature