Perinatal IL-1β-induced inflammation suppresses Tbr2⁺ intermediate progenitor cell proliferation in the developing hippocampus accompanied by long-term behavioral deficits.

ABSTRACT: Meta-analyses have revealed associations between the incidence of maternal infections during pregnancy, premature birth, smaller brain volumes, and subsequent cognitive, motor and behavioral deficits as these children mature. Inflammation during pregnancy in rodents produces cognitive and behavioral deficits in the offspring that are similar to those reported in human studies. These deficits are accompanied by decreased neurogenesis and proliferation in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. As systemically administering interleukin-1 β (IL-1β) to neonatal mice recapitulates many of the brain abnormalities seen in premature babies including developmental delays, the goal of this study was to determine whether IL-1-mediated neuroinflammation would affect hi

SUBMITTER: Veerasammy S 

PROVIDER: S-EPMC8474668 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature