Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children.

ABSTRACT:

Objective

The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups.

Study design

Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6-8 years).

Results

No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early schoo

SUBMITTER: Heard-Garris N 

PROVIDER: S-EPMC8474684 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature