Intrafractional stability of MR-guided online adaptive SBRT for prostate cancer.

ABSTRACT:

Background

MR-guided online adaptive stereotactic body radiation therapy (SBRT) for prostate cancer aims to reduce toxicity by full compensation of interfractional uncertainties. However, the process of online adaptation currently takes approximately 45 min during which intrafractional movements remain unaccounted for. This study aims to analyze the dosimetric benefit of online adaptation and to evaluate its robustness over the duration of one treatment fraction.

Methods

Baseline MR-scans at a MR-linear accelerator were acquired for ten healthy male volunteers for generation of mock-prostate SBRT plans with a dose prescription of 5 × 7.25 Gy. On a separate day, online MR-guided adaptation (ViewRay^® MRIdian) was performed, and thereafter MR images were acquired eve

SUBMITTER: Schaule J 

PROVIDER: S-EPMC8474766 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature