Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.

ABSTRACT:

Background

Maturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and defects in synaptic maturation may contribute to neurodevelopmental disorders. Neuroligin-1 (NL1) is a postsynaptic cell adhesion molecule essential for synapse maturation, a role typically attributed to binding to pre-synaptic ligands, the neurexins. However, the pathways underlying the action of NL1 in synaptic maturation are incompletely understood, and some of its previously observed effects seem reminiscent of those described for the neurotrophin brain-derived neurotrophic factor (BDNF). Here, we show that maturational increases in active zone stability and synaptic vesicle recycling rely on the joint action of NL1 and brain-derived n

SUBMITTER: Petkova-Tuffy A 

PROVIDER: S-EPMC8474808 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature