Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in NB and various other cancers that promote MYCN stabilization. In addition, both the MYCN and mTOR signaling axes can directly regulate a common translation pathway that leads to increased protein synthesis and cell proliferation. However, a strategy of concurrently targeting MYCN and mTOR signaling in NB remains unexplored. This study aimed to investigate the therapeutic potential of targeting dysregulated protein synthesis pathways by inhibiting the MYCN and mTOR pathways together in NB.

Methods

Using small molecule/pharmacologic approa

SUBMITTER: Kling MJ 

PROVIDER: S-EPMC8474810 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature