Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case-control study.

ABSTRACT:

Background

This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal women in rural China.

Methods

A case-control study with 914 participants (329 T2DM, 585 controls) was conducted. Serum progesterone was detected with liquid chromatography-tandem mass spectrometry. DNA methylation of SOCS3 was determined by MethylTarget™. Linear regression was applied to evaluate the associations of progesterone and SOCS3 methylation with marks of glucose metabolism. Logistic regression was employed to investigate the independent and combined effects of progesterone and SOCS3 methylation with T2DM in men and postmenopausal women.

Results<

SUBMITTER: Wang L 

PROVIDER: S-EPMC8474856 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature