Osteoblast-derived FGF9 regulates skeletal homeostasis.

ABSTRACT: FGF9 has complex and important roles in skeletal development and repair. We have previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein signaling and therefore the present study was done to determine whether OB-derived FGF9 was important in skeletal homeostasis. To directly test this idea, we deleted functional expression of Fgf9 gene in OBs using a 2.3kb collagen type I promoter-driven Cre transgenic mouse line (Fgf9^OB-/-). Both Fgf9 knockout (Fgf9^OB-/-) and the Fgf9 floxed littermates (Fgf9^fl/fl) mice were fully backcrossed and maintained in an FBV/N background. Three month old Fgf9^OB-/- mice displayed a significant decrease in cancellous bone and bone formation in the distal femur and a significant decrease in

SUBMITTER: Wang L 

PROVIDER: S-EPMC8474898 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature