Horizontal gene transfer-mediated bacterial strain variation affects host fitness in Drosophila.

ABSTRACT:

Background

How microbes affect host fitness and environmental adaptation has become a fundamental research question in evolutionary biology. To better understand the role of microbial genomic variation for host fitness, we tested for associations of bacterial genomic variation and Drosophila melanogaster offspring number in a microbial Genome Wide Association Study (GWAS).

Results

We performed a microbial GWAS, leveraging strain variation in the genus Gluconobacter, a genus of bacteria that are commonly associated with Drosophila under natural conditions. We pinpoint the thiamine biosynthesis pathway (TBP) as contributing to differences in fitness conferred to the fly host. While an effect of thiamine on fly development has been described, we show that strain variation in TB

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8474910 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature