Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages.

ABSTRACT:

Background

Considering the inevitability for humans to be frequently exposed to nanoparticles (NPs), understanding the biosafety of NPs is important for rational usage. As an important part of the innate immune system, macrophages are widely distributed in vital tissues and are also a dominant cell type that engulfs particles. Mitochondria are one of the most sensitive organelles when macrophages are exposed to NPs. However, previous studies have mainly reported the mitochondrial response upon high-dose NP treatment. Herein, with gold nanoparticles (AuNPs) as a model, we investigated the mitochondrial alterations induced by NPs at a sublethal concentration.

Results

At a similar internal exposure dose, different AuNPs showed distinct degrees of effects on mitochondrial altera

SUBMITTER: Jin X 

PROVIDER: S-EPMC8474914 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature