Risk reduction strategies for BRCA1/2 hereditary ovarian cancer syndromes: a clinical practice guideline.

ABSTRACT:

Objective

The purpose of this guideline is to make recommendations regarding the care of women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2.

Methods

Draft recommendations were formulated based on evidence obtained through a systematic review of RCTs, comparative retrospective studies and guideline endorsement. The draft recommendations underwent an internal review by clinical and methodology experts, and an external review by clinical practitioners.

Results

The literature search yielded 1 guideline, 5 systematic reviews, and 15 studies that met the eligibility criteria.

Conclusions

In women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2 screening for ovarian cancer is not recommended. Risk-reducing surgery i

SUBMITTER: Jacobson M 

PROVIDER: S-EPMC8474940 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature