Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients.

ABSTRACT:

Background

Malaria caused by Plasmodium falciparum results in severe complications including cerebral malaria (CM) especially in children. While the majority of falciparum malaria survivors make a full recovery, there are reports of some patients ending up with neurological sequelae or cognitive deficit.

Methods

An analysis of pooled transcriptome data of whole blood samples derived from two studies involving various P. falciparum infections, comprising mild malaria (MM), non-cerebral severe malaria (NCM) and CM was performed. Pathways and gene ontologies (GOs) elevated in the distinct P. falciparum infections were determined.

Results

In all, 2876 genes were expressed in common between the 3 forms of falciparum malaria, with CM having the least number of expressed gen

SUBMITTER: Karikari AA 

PROVIDER: S-EPMC8474955 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature