Systematic analysis of molecular characterization and clinical relevance of m6A regulators in digestive system pan-cancers.

ABSTRACT: Digestive system tumors, which mainly include esophagus, stomach, colorectum, liver, pancreas, bile duct, and some other tumors, often have a poor prognosis. N6-methyladenosine (m6A) has critical functions in development and tumorigenesis and may help improve the molecular mechanisms of digestive system tumors. However, current understanding of the reconstitution of m6A in digestive system tumors is far from comprehensive. Herein, this study systematically analyzed multi-layered genomic characteristics and clinical relevance of m6A regulators in 1906 patients involving seven digestive system tumor types. We discovered that m6A regulators showed extensive genetic changes and highly consistent expression regulation. The m6A expression was closely related to the activity of cancer pathways. A

SUBMITTER: Kou T 

PROVIDER: S-EPMC8474987 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature