Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.

ABSTRACT: Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations. Traditional eye drop was the main approach for promoting corneal wound healing. However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects. To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking. In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days. In ad

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8475096 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature