Aging, Cardiovascular Risk, and SHBG Levels in Men and Women From the General Population.

ABSTRACT:

Aims

Prior studies have reported inconsistent results for the association between sex hormone-binding globulin (SHBG) and cardiovascular disease among men and women. Although it is suggested that SHBG levels change with aging, the exact trend of SHBG across age and cardiovascular risk and the underlying mechanisms of these changes remain to be elucidated.

Methods

Using data of 3264 men and women from a large population-based cohort study, we first visualized the distribution of serum SHBG levels across age. Second, we computed a cardiovascular risk factor sum score and investigated the mean SHBG levels across categories of the risk factor sum score and stratified per age-category. Next, linear regression models were used to investigate the associations between serum SHBG lev

SUBMITTER: Aribas E 

PROVIDER: S-EPMC8475196 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature