Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study.

ABSTRACT:

Context

The association between serum thyrotropin (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established.

Objective

This work aimed to determine and analyze the causal association between serum TSH level and obesity-related traits (body mass index [BMI] and obesity).

Methods

The latest genome-wide association studies (GWASs) on TSH, BMI, and obesity were searched to obtain full statistics. Bidirectional 2-sample mendelian randomization (MR) was performed to explore the causal relationship between serum TSH and BMI and obesity. The inverse variance-weighted (IVW) and MR-Egger methods were used to combine the estimation for each single-nucleotide variation (formerl

SUBMITTER: Wang X 

PROVIDER: S-EPMC8475201 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature