Mild Idiopathic Infantile Hypercalcemia-Part 2: A Longitudinal Observational Study.

ABSTRACT:

Context

Idiopathic infantile hypercalcemia (IIH) is an uncommon disorder with variable clinical features. The natural history and response to dietary calcium and vitamin D restriction in IIH remains unclear.

Objective

The aim of this study is to describe the clinical and biochemical response to dietary calcium and vitamin D restriction in a genetically characterized cohort of mild IIH.

Methods

This is a longitudinal, observational cohort study of 20 children with mild IIH monitored for a median of 21months. Biochemical measures, dietary assessment, and yearly renal ultrasound results, since the time of diagnosis, were obtained and assessed prospectively every 4 to 6 months.

Results

Median age at initial diagnosis was 4.5 months. Median levels of serum calcium (

SUBMITTER: Lenherr-Taube N 

PROVIDER: S-EPMC8475233 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature