Usefulness of convalescent plasma transfusion for the treatment of severely ill COVID-19 patients in Pakistan.

ABSTRACT:

Background

Convalescent plasma(CP) was utilized as potential therapy during COVID-19 pandemic in Pakistan. The study aimed at appraisal of CP transfusion safety and usefulness in COVID pneumonia.

Methods

Single arm, MEURI study design of non-randomized open label trial was conducted in five centers. Patients werecategorized as moderately severe, severe, and critical. The primary endpoint was a) improvement in clinical status and change in category of disease severity; secondary endpoint was b) CP ability to halt disease progression to invasive ventilation. CP transfused to hospitalized patients. Statistical tests including median (interquartile ranges), Mann-Whitney U test, Fisher's exact test using SPSS ver. 23, ANOVA and Chi-square test were applied for the analysis of res

SUBMITTER: Khan TNS 

PROVIDER: S-EPMC8475331 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature