Microbial 5'-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications.

ABSTRACT: 5'-Nucleotidases (EC 3.1.3.5) are enzymes that catalyze the hydrolytic dephosphorylation of 5'-ribonucleotides and 5'-deoxyribonucleotides to their respective nucleosides and phosphate. Most 5'-nucleotidases have broad substrate specificity and are multifunctional enzymes capable of cleaving phosphorus from not only mononucleotide phosphate molecules but also a variety of other phosphorylated metabolites. 5'-Nucleotidases are widely distributed throughout all kingdoms of life and found in different cellular locations. The well-studied vertebrate 5'-nucleotidases play an important role in cellular metabolism. These enzymes are involved in purine and pyrimidine salvage pathways, nucleic acid repair, cell-to-cell communication, signal transduction, control of the ribo- and deoxyribonucleotide

SUBMITTER: Zakataeva NP 

PROVIDER: S-EPMC8475336 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature