Design of Monovalent and Chimeric Tetravalent Dengue Vaccine Using an Immunoinformatics Approach.

ABSTRACT: An immunoinformatics technique was used to predict a monovalent amide immunogen candidate capable of producing therapeutic antibodies as well as a potent immunogen candidate capable of acting as a universal vaccination against all dengue fever virus serotypes. The capsid protein is an attractive goal for anti-DENV due to its position in the dengue existence cycle. The widely accessible immunological data, advances in antigenic peptide prediction using reverse vaccinology, and the introduction of molecular docking in immunoinformatics have directed vaccine manufacturing. The C-proteins of DENV-1-4 serotypes were known as antigens to assist with logical design. Binding epitopes for TC cells, TH cells, and B cells is predicted from structural dengue virus capsid proteins. Each T cell epitope

SUBMITTER: Dixit NK 

PROVIDER: S-EPMC8475484 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature