Monocyte-derived S1P in the lymph node regulates immune responses.

ABSTRACT: The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where the concentration of S1P is relatively low, into circulatory fluids, where the concentration of S1P is high¹. For example, S1P directs the exit of T cells from lymph nodes, where T cells are initially activated, into lymph, from which T cells reach the blood and ultimately inflamed tissues¹. T cells follow S1P gradients primarily using S1P receptor 1 (ref. ¹). Recent studies have described how S1P gradients are established at steady state, but little is known about the distribution of S1P in disease or about how changing levels of S1P may affect immune responses. Here we show that the concentration of S1P increases in lymph nodes during an immune response. We found th

SUBMITTER: Baeyens A 

PROVIDER: S-EPMC8475585 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature