P21-activated kinase regulates oxygen-dependent migration of vascular endothelial cells in monolayers.

ABSTRACT: The collective migration of vascular endothelial cells plays important roles in homeostasis and angiogenesis. Oxygen concentration in vivo, which is lower than in the atmosphere and changes due to diseases, is a key factor affecting the cellular dynamics of vascular endothelial cells. We previously reported that hypoxic conditions promote the internalization of vascular endothelial (VE)-cadherin, a specific cell-cell adhesion molecule, and increase the velocity of the collective migration of vascular endothelial cells. However, the mechanism through which cells regulate collective migration as affected by oxygen tension is not fully understood. Here, we investigated oxygen-dependent collective migration, focusing on intracellular protein p21-activated kinase (PAK) and hypoxia-induci

SUBMITTER: Hirose S 

PROVIDER: S-EPMC8475594 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature