Diffusion MRI and anatomic tracing in the same brain reveal common failure modes of tractography.

ABSTRACT: Anatomic tracing is recognized as a critical source of knowledge on brain circuitry that can be used to assess the accuracy of diffusion MRI (dMRI) tractography. However, most prior studies that have performed such assessments have used dMRI and tracer data from different brains and/or have been limited in the scope of dMRI analysis methods allowed by the data. In this work, we perform a quantitative, voxel-wise comparison of dMRI tractography and anatomic tracing data in the same macaque brain. An ex vivo dMRI acquisition with high angular resolution and high maximum b-value allows us to compare a range of q-space sampling, orientation reconstruction, and tractography strategies. The availability of tracing in the same brain allows us to localize the sources of tractography errors and to

SUBMITTER: Grisot G 

PROVIDER: S-EPMC8475636 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature