Proteomic Signature of Dysfunctional Circulating Endothelial Colony-Forming Cells of Young Adults.

ABSTRACT: Background A subpopulation of endothelial progenitor cells called endothelial colony-forming cells (ECFCs) may offer a platform for cellular assessment in clinical studies because of their remarkable angiogenic and expansion potentials in vitro. Despite endothelial cell function being influenced by cardiovascular risk factors, no studies have yet provided a comprehensive proteomic profile to distinguish functional (ie, more angiogenic and expansive cells) versus dysfunctional circulating ECFCs of young adults. The aim of this study was to provide a detailed proteomic comparison between functional and dysfunctional ECFCs. Methods and Results Peripheral blood ECFCs were isolated from 11 subjects (45% men, aged 27±5 years) using Ficoll density gradient centrifugation. ECFCs expressed endothel

SUBMITTER: Tan CMJ 

PROVIDER: S-EPMC8475699 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature