Differential Requirement of <i>Gata2a</i> and <i>Gata2b</i> for Primitive and Definitive Myeloid Development in Zebrafish.

ABSTRACT: Germline loss or mutation of one copy of the transcription factor GATA2 in humans leads to a range of clinical phenotypes affecting hematopoietic, lymphatic and vascular systems. GATA2 heterozygous mice show only a limited repertoire of the features observed in humans. Zebrafish have two copies of the Gata2 gene as a result of an additional round of ancestral whole genome duplication. These genes, Gata2a and Gata2b, show distinct but overlapping expression patterns, and between them, highlight a significantly broader range of the phenotypes observed in GATA2 deficient syndromes, than each one alone. In this manuscript, we use mutants for Gata2a and Gata2b to interrogate the effects on hematopoiesis of these two ohnologs, alone and in combination, during development in order to further defi

SUBMITTER: Pena OA 

PROVIDER: S-EPMC8475954 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature