FiCoS: A fine-grained and coarse-grained GPU-powered deterministic simulator for biochemical networks.

ABSTRACT: Mathematical models of biochemical networks can largely facilitate the comprehension of the mechanisms at the basis of cellular processes, as well as the formulation of hypotheses that can be tested by means of targeted laboratory experiments. However, two issues might hamper the achievement of fruitful outcomes. On the one hand, detailed mechanistic models can involve hundreds or thousands of molecular species and their intermediate complexes, as well as hundreds or thousands of chemical reactions, a situation generally occurring in rule-based modeling. On the other hand, the computational analysis of a model typically requires the execution of a large number of simulations for its calibration, or to test the effect of perturbations. As a consequence, the computational capabilities of mod

SUBMITTER: Tangherloni A 

PROVIDER: S-EPMC8476010 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature