Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures.

ABSTRACT: Despite the conventional view that a truly random V(D)J recombination process should generate a highly diverse immune repertoire, emerging reports suggest that there is a certain bias toward the generation of shared/public immune receptor chains. These studies were performed in viral diseases where public T cell receptors (TCR) appear to confer better protective responses. Selective pressures generating common TCR clonotypes are currently not well understood, but it is believed that they confer a growth advantage. As very little is known about public TCR clonotypes in cancer, here we set out to determine the extent of shared TCR clonotypes in the intra-tumor microenvironments of virus- and non-virus-driven head and neck cancers using TCR sequencing. We report that tumor-infiltrating T cell

SUBMITTER: Teng YHF 

PROVIDER: S-EPMC8476067 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature