Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis.

ABSTRACT:

Background

We previously demonstrated that urine interleukin (IL)-9 and tumor necrosis factor (TNF)-α can distinguish acute interstitial nephritis (AIN) from other causes of acute kidney injury. Here we evaluated the role of these biomarkers to prognosticate kidney function in patients with AIN.

Methods

In a cohort of participants with biopsy-proven, adjudicated AIN, we tested the association of histological features and urine biomarkers (IL-9 and TNF-α) with estimated glomerular filtration rate measured 6 months after diagnosis (6 m-eGFR) controlling for eGFR before AIN and albuminuria. We also evaluated subgroups in whom corticosteroid use was associated with 6 m-eGFR.

Results

In the 51 (93%) of the 55 participants with complete data, median (interquartile range) eG

SUBMITTER: Moledina DG 

PROVIDER: S-EPMC8476079 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature