Pre-kidney transplant unintentional weight loss leads to worse post-kidney transplant outcomes.

ABSTRACT:

Background

Weight loss before kidney transplant (KT) is a known risk factor for weight gain and mortality, however, while unintentional weight loss is a marker of vulnerability, intentional weight loss might improve health. We tested whether pre-KT unintentional and intentional weight loss have differing associations with post-KT weight gain, graft loss and mortality.

Methods

Among 919 KT recipients from a prospective cohort study, we used adjusted mixed-effects models to estimate post-KT BMI trajectories, and Cox models to estimate death-uncensored graft loss, death-censored graft loss and all-cause mortality by 1-year pre-KT weight change category [stable weight (change ≤ 5%), intentional weight loss (loss > 5%), unintentional weight loss (loss > 5%) and weight gain (gain 

SUBMITTER: Harhay MN 

PROVIDER: S-EPMC8476082 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature