Inferring Long-Term Effective Population Size with Mutation-Selection Models.

ABSTRACT: Mutation-selection phylogenetic codon models are grounded on population genetics first principles and represent a principled approach for investigating the intricate interplay between mutation, selection, and drift. In their current form, mutation-selection codon models are entirely characterized by the collection of site-specific amino-acid fitness profiles. However, thus far, they have relied on the assumption of a constant genetic drift, translating into a unique effective population size (Ne) across the phylogeny, clearly an unrealistic assumption. This assumption can be alleviated by introducing variation in Ne between lineages. In addition to Ne, the mutation rate (μ) is susceptible to vary between lineages, and both should covary with life-history traits (LHTs). This suggests that t

SUBMITTER: Latrille T 

PROVIDER: S-EPMC8476147 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature