Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese.

ABSTRACT:

Aim

Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. Material and Methods. PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing.

Results

Seven SNPs were significantly associated with PsV: rs805303 (P = 0.012, OR = 0.85), rs3177928 (<

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8476246 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature