Hyperuricemia is a risk factor for the progression to end-stage renal disease in minimal change disease.

ABSTRACT:

Background

Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD.

Methods

A total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relationship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival analysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation.

Results

A total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve,

SUBMITTER: Song SH 

PROVIDER: S-EPMC8476295 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature